Beware of the interaction between vitamin B₁₂ and folic acid. Intake of supplemental folic acid should not exceed 1,000 micrograms (μg) per day to prevent folic acid from triggering symptoms of vitamin B₁₂ deficiency.¹ Folic acid supplements can correct the anemia associated with vitamin B₁₂ deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B₁₂ deficiency. Permanent nerve damage can occur if vitamin B₁₂ deficiency is not treated.

It is very important for older adults to be aware of the relationship between folic acid and vitamin B₁₂ because they are at greater risk of having a vitamin B₁₂ deficiency. If you are 50 years of age or older, ask your physician to check your B₁₂ status before you take a supplement that contains folic acid. If you are taking a supplement containing folic acid, read the label to make sure it also contains B₁₂ or speak with a physician about the need for a B₁₂ supplement.

Related Links: What is folate? | What are some important links between folate and my health? | What foods provide folate? | How much folate do I need? | What happens if I do not get enough folate? | Do I need extra folate? | Can folate be harmful? | What are some of the current issues and controversies about folate? | Does folate interact with any medicines or supplements?

Disclaimer

Reasonable care has been taken in preparing this document and the information provided herein is believed to be accurate. However, this information is not intended to constitute an "authoritative statement" under Food and Drug Administration rules and regulations.

About Source: ODS

The mission of the Office of Dietary Supplements (ODS) is to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, stimulating and supporting research, disseminating research results, and educating the public to foster an enhanced quality of life and health for the U.S. population.

General Safety Advisory

Health professionals and consumers need credible information to make thoughtful decisions about eating a healthful diet and using vitamin and mineral supplements. These Fact Sheets provide responsible information about the role of vitamins and minerals in health and disease. Each Fact Sheet in this series received extensive review by recognized experts from the academic and research communities.

The information is not intended to be a substitute for professional medical advice. It is important to seek the advice of a physician about any medical condition or symptom. It is also important to seek the advice of a physician, registered dietitian, pharmacist, or other qualified health professional about the appropriateness of taking dietary supplements and their potential interactions with medications.

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Footnotes

1. Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. National Academy Press. Washington, DC, 1998. [↩]